Muscle Clicker 2 is the second installment of the popular click-tap Muscle Clicker series that features incremental muscle-building play. The player needs to help a character with small muscles or muscle wasting increase their mass through the use of barbells, a beach ball, dumbbells, an exercise bike and a treadmill. They must also help the character win weight-lifting contests and other competitive events.
The game starts in a city-view living room decorated with minimalist post-modern furniture. As in the previous game, the player clicks, taps or presses the game screen to prompt the character to exercise using one of the available methods.
The player uses icons at the top of the screen to make adjustments to the character, exercise options and overall game. They use the first icon, marked with six small shapes, to pick competitions and exercises. The icon marked with a figure allows them to increase the character's stamina and strength.
With the backpack icon, they can select hairstyles, hats, shoes and unlocked backgrounds. They use the shopping cart icon to buy new exercise gear and stimulants. Lastly, they use the icon marked with two nuts to change music and sounds. This game comes with six selectable music tracks.
Muscle Click 2 tracks the player's experience with Progress Bar 1 and stamina with Progress Bar 2. The player can track the money they save next to a coin below these bars. They then later use the coins to upgrade gear and stimulants, which they can adjust with the up and down arrows to the right and left of the character, respectively.