Human Evolution Rush is a three-dimensional, evolution-based, stickman fighting and racing game. The player directs a stickman down a racetrack toward gates and red enemy fighters. The character automatically starts running and throwing weapons in front of it the moment the player begins the run. The player's goal is to increase the number of characters and evolve them into more powerful ones before they reach the final fighting area at the end of the track.
The player can improve their stickman's chances by performing running speed and fighting upgrades or increasing the number of fighters at the start of the race. They only need to pay for the option or watch an advertisement. They can also direct their character through gates on the track that increase the amount of cash and fighters or generate the next stage of evolution. After a successful run, they can claim a multiplier if they watch an ad.
During gameplay, the player might direct the stickman to run in the line of sight of a red enemy stickman to defeat the soldier before the character ever reaches their location. They might also need to save blue hostages. At the end of the run, they typically face off against enemy troops and a giant while fighting from behind sandbags.
Human Evolution Rush allows the player to upgrade people, eras, phones, weapons and pets with cash. They can also perform upgrades by watching advertisements. The player can even remove plus and minus gates by watching an ad.